Home

Accredited DNA Analysis Services

Solutions for Sample Mixtures

FRISC™ for Spent Shell Casings

Center for Advanced Genomics

About Signature Science, LLC

Signature Science, LLC’s accredited forensic DNA laboratories offer state-of-the-art forensic serology, DNA analysis, and Forensic Genetic Genealogy services. We support our clients with cost-effective, scalable casework solutions for both traditional and specialized sample analysis. Further, to address the scientific and technical forensic challenges facing our criminal justice system, Signature Science engages in genomic research, development, and testing and evaluation activities in our Center for Advanced Genomics.

Lab technician at a hooded workstation

Casework Services

Forensic Genetic Genealogy

No Match in CODIS?
Consider this Next Step.

Forensic genetic genealogy (FGG) is a different approach to develop investigative leads for your cold case or active case that has not returned a DNA match in the CODIS database. FGG uses advanced DNA workflows to generate a SNP profile for upload to public genetic genealogy database(s) authorized for law enforcement use to search for familial links. MORE

Magnifying glass enlarging a strand of DNA.
Icon showing magnifying glass and strand of DNA

Forensic DNA Analysis

Our casework laboratories deliver high-quality analyses to our clients at the federal, state, and local levels. On-time. Every time.

Icon of clipboard with strand of dna and a checkmark in a circle

Case and Data Review

Meet with us and walk our experts through the details of your case. We’ll help you uncover the best, most cost-effective evidence testing plan.

Icon showing courthouse and scales of justice

Expert Witness Testimony

Each analyst involved in your case is trained and adept at delivering expert witness testimony that juries can understand.

Shell Casing Analysis

Our approach to DNA recovery from spent shell casings maximizes DNA recovery without compromising downstream ballistics testing.

Resources

Signature Science’s experts advance the capabilities of forensic science applications with research and development of new methods and laboratory automation software. To support the continuous improvement of forensic laboratory operations, we offer technical workshops, presentations, and tailored training.

Center for Advanced Genomics®
In our Center for Advanced Genomics®, we develop and validate novel methods for maximizing DNA recovery in both yield and quality from challenging samples. We evaluate and optimize sequencing and genotyping technologies for forensic applications.

Abstract image of biological material

Bioinformatics Tools
Our bioinformaticians develop tailored workflow tools and solutions to achieve automation objectives for forensic laboratory operations.

Photo of young woman giving a presentation

Research & Technical Presentations
Our DNA analysts and forensic scientists contribute to the forensic science community through workshops and presentations on impactful topics.

Photo of a classroom with instruction underway

Training & Validation Services
Our training courses and validation services are tailored to the needs of individual laboratories, departments, and agencies.

Image of floating dollar signs

Funding Resources
Several federal programs offer law enforcement and non-profit organizations funding support at the local and state level.

Collage of title slides from four presentations: From Lab to Verdict, Necessity is the Mother of Innovation, Internal Validation of the ForenSeq Kintelligence, and Unlocking Dependable Forensic Results from Shell Casings.

For a great collection of informative presentations, visit Research & Technical Presentations.

Forensic DNA News

See All News

Stylized illustration of a DNA helix

Signature Science Achieves ISO/IEC 17025:2017 Accreditation for Massively Parallel Sequencing (MPS)

Achievement builds on Company’s forensic science laboratory’s accreditation scope and expands its accredited offerings into the Forensic Genetic Genealogy space. AUSTIN, TEXAS – February 25, 2025 – Signature Science’s Advanced Genomics Laboratory has been issued accreditation by ANAB, the ANSI National … MORE

Thumbnail for Horizon Newsletter - February 2025

Horizon Newsletter – February 2025

Laboratory Leadership at AAFS Documentary standards play a critical role in ensuring consistency, quality, and credibility in forensic science. Hosted in collaboration with Travis County Medical Examiner’s Office, our Deep-Dive session at AAFS will explore the importance of standards development, how … MORE

Jumbled knot with a single strand emerging to the right. Text reads "Article Published in FSI Genetics."

Published in “FSI Genetics”: MixDeR: A SNP mixture deconvolution workflow for forensic genetic genealogy

Published in “FSI Genetics”: MixDeR: A SNP mixture deconvolution workflow for forensic genetic genealogy Abstract: The generation of forensic DNA profiles consisting of single nucleotide polymorphisms (SNPs) is now being facilitated by wider adoption of next-generation sequencing (NGS) methods in casework laboratories. … MORE

Next Steps…

Let’s Discuss Your Case

Ready to Submit a Case?