Signature Science has validated a SNP mixture deconvolution workflow for two-person DNA mixtures, a breakthrough enabling new leads from evidence previously unusable. When a sample contains DNA from two contributors, our process separates the mixture to produce a single-source SNP profile for the major contributor, making it suitable for forensic investigative genetic genealogy (FIGG) analysis. The advent of this technology means that more evidence types can be considered for FIGG. Critically, depending on the mixture ratio, our workflow can be used with or without a reference sample. Unsure if your sample is a good fit? Leave it to us! We will evaluate … MORE
Abstract: This study evaluated the ability to produce FORensic Capture Enrichment (FORCE) genotypes using amplicon-based and capture-based enrichment assays. The FORCE panel is a standardized set of single nucleotide polymorphism (SNP) markers developed for forensic applications. Twelve DNA samples were … MORE
Horizon Newsletter – February 2026
We’re gearing up for another ASCLD Symposium and are excited to be part of 2026’s packed agenda! We’re hosting two plenary talks and one deep dive session. Scroll for a preview of SigSci Forensics on the agenda. Dates & Times TBA! View … MORE
Horizon Newsletter – November 2025
Collaboration Leads to Breakthrough in a Case That’s Close to Home After over 30 years, breakthroughs in forensic science have led investigators to identify a person of interest in the 1991 murders of four young Austin-area girls; Eliza Thomas, Amy Ayers, … MORE
Authorized Statement on the Yogurt Shop Murders Investigation
October 07, 2025 – After over 30 years, breakthroughs in forensic science have led investigators to identify a person of interest in the 1991 murders of four young Austin-area girls; Eliza Thomas, Amy Ayers, and sisters Jennifer Harbison and Sarah Harbison. Announced at a media briefing held by the City of Austin on Monday, 9/29, this development in the “Yogurt Shop Murders” case represents the outcome of years of tireless commitment, open communication, and coordinated efforts across the forensic and law enforcement communities. In keeping with our confidentiality policies and professional obligations, Signature Science does not comment on specific cases without … MORE
Horizon Newsletter – July 2025
We’re excited to launch our new dedicated forensics website designed to make working with Signature Science easier and more efficient than ever before! The new website features: Comprehensive Forensic DNA Testing Services – In-depth information on our full suite of forensic DNA testing capabilities Streamlined … MORE
Our Interns’ Summer with SigSci Forensics
Each summer, Signature Science, LLC welcomes at least one intern to assist with research in our Center for Advanced Genomics (CAG). The research and validations performed at the CAG are shared with the forensic community in the form of open-source … MORE
Horizon Newsletter – April 2025
Accredited FGG Services to Better Serve You! Signature Science’s Advanced Genomics Laboratory has been accredited by the ANSI National Accreditation Board (ANAB) to the ISO/IEC 17025:2017 quality standard for forensic testing of Single-Nucleotide Polymorphisms (SNPs). As part of the accreditation process, our … MORE
Signature Science Achieves ISO/IEC 17025:2017 Accreditation for Massively Parallel Sequencing (MPS)
Achievement builds on Company’s forensic science laboratory’s accreditation scope and expands its accredited offerings into the Forensic Genetic Genealogy space. AUSTIN, TEXAS – February 25, 2025 – Signature Science’s Advanced Genomics Laboratory has been issued accreditation by ANAB, the ANSI National … MORE
Horizon Newsletter – February 2025
Laboratory Leadership at AAFS Documentary standards play a critical role in ensuring consistency, quality, and credibility in forensic science. Hosted in collaboration with Travis County Medical Examiner’s Office, our Deep-Dive session at AAFS will explore the importance of standards development, how … MORE
Published in “FSI Genetics”: MixDeR: A SNP mixture deconvolution workflow for forensic genetic genealogy Abstract: The generation of forensic DNA profiles consisting of single nucleotide polymorphisms (SNPs) is now being facilitated by wider adoption of next-generation sequencing (NGS) methods in casework laboratories. … MORE