Stylized DNA helix in front of GATCs with checkmark. Text reads "Internal Validation of Enhanced Laboratory Methods for ForenSeq® Kintelligence Kit"
January 11, 2023

Published in “Forensic Genomics”: Internal Validation of the ForenSeq® Kintelligence Kit for Application to Forensic...

Abstract Forensic Genetic Genealogy (FGG) requires high-density single nucleotide polymorphism (SNP) profiles to infer distant relationships. The ForenSeq Kintelligence kit is a recently developed method targeting 10,230 SNPs that were selected to be compatible with genetic genealogy databases, whereas avoiding medically relevant SNPs. The targeted polymerase chain reaction method is... MORE
Profile of a human head filled with DNA testing strips
January 1, 2023

Founders Announce Establishment of the National Technology Validation and Implementation Collaborative (NTVIC) and Forensic Investigative...

In a paper published in Forensic Science International: Synergy, founders of the National Technology Validation and Implementation Collaborative (NTVIC) announced the group’s formation, in addition to the formation of its first Technology Validation Working Group, the Forensic Investigative Genetic Genealogy Technology Validation Group (FIGG-TVG). Signature Science’s Center for Advanced Genomics is proud to... MORE
Stylized DNA helix in front of GATCs with checkmark. Text reads "Internal Validation of Enhanced Laboratory Methods for ForenSeq® Kintelligence Kit"
November 1, 2022

Internal Validation of the ForenSeq Kintelligence Kit for Application to Forensic Genetic Genealogy

Abstract: Forensic Genetic Genealogy (FGG) requires high density single nucleotide polymorphism (SNP) profiles to infer distant relationships. The ForenSeq Kintelligence kit is a recently developed method targeting approximately 10,000 SNPs that were selected to be compatible with genetic genealogy databases, while avoiding medically relevant SNPs. The targeted PCR method is... MORE
Thumbnail for Horizon Newsletter - October 2022
October 30, 2022

HORIZON Newsletter – October 2022

The Center for Advanced Genomics is heading to DC for ISHI 2022, and we are excited to see you all there! Meet our experts, exchange ideas, and learn about the validated novel forensic DNA methods and technologies developed in the CAG. Arrange a meetup before you go, or plan to stop... MORE
Diagram of a ball-and-stick model. Text reads "Relationship Inference Paper Published; Featured in Forensic Genomics".
October 6, 2022

Paper Published in “Forensic Genomics”: Relationship Inference with Low-Coverage Whole Genome Sequencing on Forensic Samples

Abstract Background: Single nucleotide polymorphism (SNP)-based kinship analysis is now a cornerstone of modern forensic genomics. Imputation can be used to augment genome-wide SNP data from low-coverage whole-genome sequencing (LCWGS). The impact of imputation after LCWGS on genotyping error and its subsequent impact on kinship analysis are unknown. Methods: We assessed the... MORE
Collage with a cityscape in the background and an overlay diagram of connected people. Text reads "Kinship Analysis".
September 13, 2022

SigSci Scientists Co-Author Study Published in “Frontiers in Genetics”

Abstract: Technological advances in sequencing and single nucleotide polymorphism (SNP) genotyping microarray technology have facilitated advances in forensic analysis beyond short tandem repeat (STR) profiling, enabling the identification of unknown DNA samples and distant relationships. Forensic genetic genealogy (FGG) has facilitated the identification of distant relatives of both unidentified remains... MORE
Thumbnail for Horizon Newsletter - August 2022
August 4, 2022

HORIZON Newsletter – August 2022

The Center for Advanced Genomics hits the road in August! We’re headed to scientific conferences and training symposia across the country. Catch up with us at: IHIA | New Orleans, LA | August 7-9 CHIA | Las Vegas, NV | August 23-26 ISFG | Washington, DC | August 29- Sept.... MORE
Thumbnail for Horizon Newsletter - April 2022
April 21, 2022

HORIZON Newsletter – April 2022

CAG Heads to Reno Leaders from our ANAB-Accredited Forensic DNA Laboratory are presenting and exhibiting at the American Society of Crime Laboratory Directors (ASCLD) Annual Symposium next week! Their respective experiences working for a forensic laboratory in the midst of a global pandemic, and leading a laboratory-wide LIMS transition from homemade... MORE